Tigran Mikayelyan was born in Yerevan/Armenia and trained at the Armenian Ballet school Erewan from 1989-1997. In 1997 he got a scholarship from the Nurejev-Foundation and joined the Suisse Ballet Academy SBBS in Zurich. He won several international prizes including the 1st Prize in the Armenian Ballet Competition Amadeus as well as the Prix Niveau Professional of the Prix de Lausanne. Having graduated in 1998 he was engaged with the Zurich Ballet where he promoted to soloist in 1999 and to first soloist in 2003. During his time at the Zurich Ballet he danced a broad repertoire of Heinz Spoerli's choreographies as well as the part of Dorkon in Daphnis und Chloé, the Solo-Boy in Rubies, in Hans van Manen's Solo and Große Fuge as well as Allegro Brillante by George Balanchine.
In 2005/2006 he joined the Bavarian State Ballet as a first Soloist and was promoted to Principal at the beginning of the season 2007/2008.
In 2007, his home country announced Tigran Mikayelyan as Honoured Artist of Armenia, the highest appreciation artists of his country can achieve.
In summer 2007 he received the theatre award of the Münchner Merkur.
Among his principal parties Mercutio and Romeo (Romeo and Juliet, J. Cranko), Prince Siegfried (Swan lake, R. Barra), Solor (La Bayadère, Bart), Des Grieux (Lady of the Camelias, J. Neumeier), Faun (L'après-midi d'un faune, V. Nijinsky), Lenski (Onegin, J. Cranko), Prince Désire (Sleeping Beauty, M. Petipa, I. Liška), Basilio (Don Quijote, M. Petipa, new choreography by R. Barra, A. Gorski), Petrucchio (The Taming of the Shrew, J. Cranko). Also he danced in ballets of J. Godani, W. Forsythe, J. Mannes, K. MacMillan, T. Kohler, J. Robbins, J. Limón, L. Massine.